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Condition: Kidney Transplantation

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Total 40023 results found since Jan 2013.

Swine hepatitis E virus: cross-species infection, pork safety and chronic infection.
Abstract Swine hepatitis E virus (swine HEV) belongs to the species Orthohepevirus A within the genus Orthohepevirus in the family Hepeviridae. Four different genotypes of swine HEV within the species Orthohepevirus A have been identified so far from domesticated and wild swine population: genotypes 3 (HEV-3) and 4 (HEV-4) swine HEVs are zoonotic and infect humans, whereas HEV-5 and HEV-6 are only identified from swine. As a zoonotic agent, swine HEV is an emerging public health concern in many industrialized countries. Pigs are natural reservoir for HEV, consumption of raw or undercooked pork is an important rout...
Source: Virus Research - April 21, 2020 Category: Virology Authors: Sooryanarain H, Meng XJ Tags: Virus Res Source Type: research

Xenotransplantation tolerance: applications for recent advances in modified swine.
Abstract PURPOSE OF REVIEW: The aim of this study was to review the recent progress in xenotransplantation achieved through genetic engineering and discuss the potential of tolerance induction to overcome remaining barriers to extended xenograft survival. RECENT FINDINGS: The success of life-saving allotransplantation has created a demand for organ transplantation that cannot be met by the supply of human organs. Xenotransplantation is one possible solution that would allow for a nearly unlimited supply of organs. Recent genetic engineering of swine has decreased the reactivity of preformed antibodies to some...
Source: Current Opinion in Organ Transplantation - November 2, 2018 Category: Transplant Surgery Authors: Llore NP, Bruestle KA, Griesemer A Tags: Curr Opin Organ Transplant Source Type: research

Xenotransplantation tolerance: applications for recent advances in modified swine
Purpose of review The aim of this study was to review the recent progress in xenotransplantation achieved through genetic engineering and discuss the potential of tolerance induction to overcome remaining barriers to extended xenograft survival. Recent findings The success of life-saving allotransplantation has created a demand for organ transplantation that cannot be met by the supply of human organs. Xenotransplantation is one possible solution that would allow for a nearly unlimited supply of organs. Recent genetic engineering of swine has decreased the reactivity of preformed antibodies to some, but not all, poten...
Source: Current Opinion in Organ Transplantation - November 2, 2018 Category: Surgery Tags: XENOTRANSPLANTATION: Edited by Andrew Adams Source Type: research

The Induction of Tolerance of Renal Allografts by Adoptive Transfer in Miniature Swine
In this study, we attempted to induce tolerance of class I‐mismatched kidneys by adoptive transfer of cells and/or kidneys from long‐term tolerant animals. Fifteen SLAdd miniature swine received 1.5 Gy whole body irradiation and class I‐mismatched (SLAgg) kidneys from naïve pigs with or without cotransplanted kidneys and/or adoptively transferred cells from long‐term tolerant (LTT) SLAdd recipients of SLAgg grafts. In addition, three SLAdd miniature swine received class I mismatched kidney with adoptively transferred cells from LTT SLAdd recipients. Naïve kidneys transplanted without a LTT kidney were rejected wi...
Source: American Journal of Transplantation - March 6, 2013 Category: Transplant Surgery Authors: M. Okumi, J. R. Scalea, B. C. Gillon, M. Tasaki, V. Villani, T. Cormack, A. Hirakata, A. Shimizu, D. H. Sachs, K. Yamada Tags: Original Article Source Type: research

The effects of the WT1 gene on apoptosis and development‐related gene expression in porcine kidney fibroblasts and swine testis cells
Abstract The Wilm's tumor 1 gene (WT1) encodes zinc finger proteins that function as tumor suppressors, and play important roles in the development of the genito‐urinary system and other organs. Its precise function in the development of porcine tissues and organs, which is an attractive transplantation resource for certain human diseases, is still unclear. Here, we sought to define the role of WT1 in porcine kidney and testis tissues using porcine kidney fibroblasts (PKFs) and swine testis (ST) cells as in vitro models, both of which express WT1. The recombinant plasmids pLV3‐WT1 shRNA and pIRES2‐WT1‐EGFP were con...
Source: Molecular Reproduction and Development - April 4, 2013 Category: Reproduction Medicine Authors: Peipei An, Yupeng Yin, Anran Fan, Wentao Tan, Fei Gao, Kuiying Ma, Bo Tang, Xueming Zhang, Ziyi Li Tags: Research Article Source Type: research

Acute Rejection After Swine Leukocyte Antigen-Matched Kidney Allo-Transplantation in Cloned Miniature Pigs With Different Mitochondrial DNA-Encoded Minor Histocompatibility Antigen
Conclusion: Cloned pigs are a useful preclinical model to evaluate the immunogenicity of mtDNA encoding minor antigens. The mtDNA originating from nongenomic DNA induced cell-mediated immune rejection after kidney transplantation.
Source: Transplantation Proceedings - June 1, 2013 Category: Transplant Surgery Authors: H.-H. Kwak, K.-M. Park, P.K. Teotia, G.-S. Lee, E.-S. Lee, S.-H. Hong, S.-R. Yang, S.-M. Park, C. Ahn, C.-K. Park, K.-W. Lee, H.-M. Woo Tags: Experimental Transplantation Source Type: research

Induction of Cardiac Allograft Tolerance Across a Full MHC Barrier in Miniature Swine by Donor Kidney Cotransplantation
Abstract We have previously shown that tolerance of kidney allografts across a full major histocompatibility complex (MHC) barrier can be induced in miniature swine by a 12‐day course of high‐dose tacrolimus. However, that treatment did not prolong survival of heart allografts across the same barrier. We have now tested the effect of cotransplanting an allogeneic heart and kidney from the same MHC‐mismatched donor using the same treatment regimen. Heart allografts (n = 3) or heart plus kidney allografts (n = 5) were transplanted into MHC‐mismatched recipients treated with high‐dose tacrolimus for 12 days....
Source: American Journal of Transplantation - August 1, 2013 Category: Transplant Surgery Authors: M. L. Madariaga, S. G. Michel, M. Tasaki, V. Villani, G. M. La Muraglia, S. Sihag, J. Gottschall, E. A. Farkash, A. Shimizu, J. S. Allan, D. H. Sachs, K. Yamada, J. C. Madsen Tags: Original Article Source Type: research

Kidney‐Induced Cardiac Allograft Tolerance in Miniature Swine is Dependent on MHC‐Matching of Donor Cardiac and Renal Parenchyma
Kidney allografts possess the ability to enable a short course of immunosuppression to induce tolerance of themselves and of cardiac allografts across a full‐MHC barrier in miniature swine. However, the renal element(s) responsible for kidney‐induced cardiac allograft tolerance (KICAT) are unknown. Here we investigated whether MHC disparities between parenchyma versus hematopoietic‐derived “passenger” cells of the heart and kidney allografts affected KICAT. Heart and kidney allografts were co‐transplanted into MHC‐mismatched recipients treated with high‐dose tacrolimus for 12 days. Group 1 animals (n = ...
Source: American Journal of Transplantation - March 30, 2015 Category: Transplant Surgery Authors: M. L. Madariaga, S. G. Michel, G. M. La Muraglia, M. Sekijima, V. Villani, D. A. Leonard, H. J. Powell, J. M. Kurtz, E. A. Farkash, R. B. Colvin, J. S. Allan, C. L. Cetrulo, Jr, C. A. Huang, D. H. Sachs, K. Yamada, J. C. Madsen Tags: Original Article Source Type: research

The Effects of Kidney Graftectomy on the Tolerance Induced By Heart-Kidney Cotransplantation in Miniature Swine Depends on the MHC Barrier Crossed
We have previously demonstrated that isolated hearts transplanted in miniature swine across an MHC class I barrier and treated with 12 days of CyA or transplanted across a full MHC barrier and treated with FK506 rejected their allografts within 55 days. In contrast, hearts co-transplanted with kidneys and transplanted across the same MHC barriers with the identical treatment survived indefinitely. The kidney allografts were explanted from the class I mismatch recipients more than 100 days after the transplant and replaced with recipient-matched kidneys.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: S.G. Michel, M.L. Madariaga, G.M. LaMuraglia, V. Villani, M. Sekijima, E.A. Farkash, R. Colvin, J.S. Allan, K. Yamada, D.H. Sachs, J.C. Madsen Source Type: research

Effects of Lung Cotransplantation on Cardiac Allograft Tolerance Across a Full Major Histocompatibility Complex Barrier in Miniature Swine
A 12‐day course of high‐dose tacrolimus induces tolerance of major histocompatibility complex–mismatched lung allografts in miniature swine but does not induce tolerance of heart allografts unless a kidney is cotransplanted. To determine whether lungs share with kidneys the ability to induce cardiac allograft tolerance, we investigated heart–lung cotransplantation using the same induction protocol. Hearts (n = 3), heart–kidneys (n = 3), lungs (n = 6), and hearts–lungs (n = 3) were transplanted into fully major histocompatibility complex–mismatched recipients treated with high‐dose tacrolimus...
Source: American Journal of Transplantation - October 1, 2015 Category: Transplant Surgery Authors: M. L. L. Madariaga, P. J. Spencer, S. G. Michel, G. M. La Muraglia, M. J. O’Neil, E. C. Mannon, C. Leblang, I. A. Rosales, R. B. Colvin, D. H. Sachs, J. S. Allan, J. C. Madsen Tags: Brief Communication Source Type: research

Chimeric Allografts Induced by Short‐Term Treatment with Stem Cell Mobilizing Agents Result in Long‐term Kidney Transplant Survival without Immunosuppression: II Study in Miniature Swine
This article is protected by copyright. All rights reserved.
Source: American Journal of Transplantation - January 8, 2016 Category: Transplant Surgery Authors: Andrew M Cameron, Russell Wesson, Ali Ahmadi, Andrew L Singer, Xiaopeng Hu, Takehiro Okabayashi, Yongchun Wang, Masatoshi Shigoka, Yingxin Fu, Wei Gao, Lorraine C Raccusen, Robert A Montgomery, George Melville Williams, Zhaoli Sun Tags: Original Article Source Type: research

Swine Leukocyte Antigen Class II Is a Xenoantigen
Conclusions Class II SLA proteins may behave as xenoantigens for people with humoral immunity toward class II HLA molecules.
Source: Transplantation - January 31, 2018 Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research

High-performance information search filters for acute kidney injury content in PubMed, Ovid Medline and Embase
Conclusions PubMed, Ovid Medline and Embase can be filtered for articles relevant to AKI in a reliable manner. These high-performance information filters are now available online and can be used to better identify AKI content in large bibliographic databases.
Source: Nephrology Dialysis Transplantation - March 27, 2014 Category: Urology & Nephrology Authors: Hildebrand, A. M., Iansavichus, A. V., Haynes, R. B., Wilczynski, N. L., Mehta, R. L., Parikh, C. R., Garg, A. X. Tags: Acute Kidney Injury Source Type: research

Fibrinogen: A Circulating Factor in Search for Its Genetic Architecture.
Abstract Fibrinogen (Coagulation factor I) is a major player in thrombus formation; it is cleaved by thrombin to form fibrin, which is the most abundant component of a blood clot(1). Beyond the role played in the coagulation and cardiovascular diseases (CVD), fibrinogen is a proinflammatory factor in autoimmune and inflammatory diseases (such as rheumatoid arthritis, vasculitides, inflammatory bowel disease, multiple sclerosis, chronic obstructive pulmonary diseases and kidney disorders and post-transplant-fibrosis)(2) as well as in several types of cancer(3). Fibrinogen has been demonstrated to interfere with the...
Source: Circulation - August 22, 2013 Category: Cardiology Authors: Arbustini E, Narula N, D'Armini AM Tags: Circulation Source Type: research

Blood biomarkers of kidney transplant rejection, an endless search?
Authors: Jacquemont L, Soulillou JP, Degauque N Abstract INTRODUCTION: The tailoring of immunosuppressive treatment is recognized as a promising strategy to improve long-term kidney graft outcome. To guide the standard care of transplant recipients, physicians need objective biomarkers that can identify an ongoing pathology with the graft or low intensity signals that will be later evolved to accelerated transplant rejection. The early identification of "high-risk /low-risk" patients enables the adjustment of standard of caring, including managing the frequency of clinical visits and the immunosuppression dosing. G...
Source: Expert Review of Molecular Diagnostics - June 4, 2017 Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research